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Watch Carefully (3)pentobarbital will lower the level or outcome of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Solid or average CYP3A4 inducers may possibly enhance amount of diazepam elimination; as a result, efficacy of diazepam can be decreased.pentobarbital will reduce the level or o